Shop Home About Us Contact FAQ Science Blog Become A Distributor C-Max
English
USD
C-Max
C-Max
C-Max
C-Max
C-Max
C-Max
C-Max
C-Max

C-Max

$225.00
Many in stock
Description

 

  • Synergistic vitamins shown to kill 10-times cancer more efficiently than high-dose vitamin C alone
  • Unlike conventional therapies, C-Max is safe to normal human cells
  • Delivered via liposomes sized for maximum tumor absorption
  • Made in USA at FDA, GMP-certified facilities
  • Drinkable and portable: IV doses anywhere
  • Non-GMO; soy, gluten, sugar, alcohol, allergen, and heavy metal-free.

    TESTIMONIALS

    Authentic feedback on C-Max from cancer patients:

    "I have fantastic news. I discontinued all hormone suppression (ADT) over a month ago against doctors advice and have skipped all treatments at my last oncology visit. Been doing Cmax!!! Just got my lab results today (attached), check this out:

    Testosterone: 994!!! Up from 18 last month
    PSA = 0.1 ng; no change from last month! negligible
    Alk Phos: 116, down from 136 last month. Evidence metastases are diminished.

    I had done 9 weeks of Cesium Chloride as well and stopped it 2 weeks ago as I felt it had done its work.

    Praise God!!!! Thank you IVTOGO!!!"
    Larry Rison
    Author details

    "I wanted to report my success with C-Max. After 30 days of C-Max, PSA came down 50 points. After that, I tried AHCC for a month and PSA went up from 78 to 85. It is working!"
    David Waters

    C-Max has worked very well or me. I had six spots on my lungs. After taking C-Max for 6 1/2 months, and some immune therapy, all six spots are gone!

    During COVID, some of my customers in Jordan were on the IVtoGo product and were able to get over it very quickly.

    I find both products to be excellent.
    Mike Trumpower

    I want to thank you for making this product! If it weren't for C-Max, I would not be alive!
    Jane Strachan

    "I have fantastic news. I discontinued all hormone suppression (ADT) over a month ago against doctors advice and have skipped all treatments at my last oncology visit. Been doing Cmax!!! Just got my lab results today (attached), check this out:

    Testosterone: 994!!! Up from 18 last month
    PSA = 0.1 ng; no change from last month! negligible
    Alk Phos: 116, down from 136 last month. Evidence metastases are diminished.

    I had done 9 weeks of Cesium Chloride as well and stopped it 2 weeks ago as I felt it had done its work.

    Praise God!!!! Thank you IVTOGO!!!"
    Larry Rison
    Author details

    "I wanted to report my success with C-Max. After 30 days of C-Max, PSA came down 50 points. After that, I tried AHCC for a month and PSA went up from 78 to 85. It is working!"
    David Waters

    C-Max has worked very well or me. I had six spots on my lungs. After taking C-Max for 6 1/2 months, and some immune therapy, all six spots are gone!

    During COVID, some of my customers in Jordan were on the IVtoGo product and were able to get over it very quickly.

    I find both products to be excellent.
    Mike Trumpower

    I want to thank you for making this product! If it weren't for C-Max, I would not be alive!
    Jane Strachan

    "I have fantastic news. I discontinued all hormone suppression (ADT) over a month ago against doctors advice and have skipped all treatments at my last oncology visit. Been doing Cmax!!! Just got my lab results today (attached), check this out:

    Testosterone: 994!!! Up from 18 last month
    PSA = 0.1 ng; no change from last month! negligible
    Alk Phos: 116, down from 136 last month. Evidence metastases are diminished.

    I had done 9 weeks of Cesium Chloride as well and stopped it 2 weeks ago as I felt it had done its work.

    Praise God!!!! Thank you IVTOGO!!!"
    Larry Rison
    Author details

    "I wanted to report my success with C-Max. After 30 days of C-Max, PSA came down 50 points. After that, I tried AHCC for a month and PSA went up from 78 to 85. It is working!"
    David Waters

    C-Max has worked very well or me. I had six spots on my lungs. After taking C-Max for 6 1/2 months, and some immune therapy, all six spots are gone!

    During COVID, some of my customers in Jordan were on the IVtoGo product and were able to get over it very quickly.

    I find both products to be excellent.
    Mike Trumpower

    I want to thank you for making this product! If it weren't for C-Max, I would not be alive!
    Jane Strachan

    How C-Max Works

    Better Than Vitamin C Alone

    Vitamin C works together with K3 and Lipoic Acid to make cancer cells self-destruct.

    Read more
    Helps Your Immune Cells "See"

    Vitamin C and K3 together allow your immune system to "see" cancer cells better, enhancing your ability to kill them.

    Better Tumor Absorption

    C-Max liposomes are particles specifically designed to "get in" to tumors. During production, C-Max liposomes are tightly controlled so as to conform to the appropriate size for maximum tumor penetration.

    SAFE for your body

    Unlike many cancer medications, C-Max does not attack your body. While they kills cancer, the vitamins in C-max are totally safe for normal cells. In fact, C-Max vitamins have passed stage two FDA trials for safety.

    Big pharma companies won't release these vitamins simply because they can't be patented.

    Better Than Vitamin C Alone

    Vitamin C works together with K3 and Lipoic Acid to make cancer cells self-destruct.

    Read more
    Helps Your Immune Cells "See"

    Vitamin C and K3 together allow your immune system to "see" cancer cells better, enhancing your ability to kill them.

    Better Tumor Absorption

    C-Max liposomes are particles specifically designed to "get in" to tumors. During production, C-Max liposomes are tightly controlled so as to conform to the appropriate size for maximum tumor penetration.

    SAFE for your body

    Unlike many cancer medications, C-Max does not attack your body. While they kills cancer, the vitamins in C-max are totally safe for normal cells. In fact, C-Max vitamins have passed stage two FDA trials for safety.

    Big pharma companies won't release these vitamins simply because they can't be patented.

    "CK3 kills cancer cells, leaving healthy cells intact."

    Leading oncology researchers agree: CK3 just works. When it's time to follow the science on cancer, C-Max is ready.

    "CK3 kills cancer cells, leaving healthy cells intact."

    Leading oncology researchers agree: CK3 just works. When it's time to follow the science on cancer, C-Max is ready.

    C-Max Vitamin Effects on Cancer Types

    The C-Max vitamins are effective for a wide variety of cancer types:
    Bladder Cancer

    Gilloteaux J, Jamison JM, Neal DR, Loukas M, Doberzstyn T, Summers JL. Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione. Ultrastruct Pathol. 2010 May;34(3):140-60. doi: 10.3109/01913121003662304. PMID: 20455663.


    Jamison JM, Gilloteaux J, Perlaky L, Thiry M, Smetana K, Neal D, McGuire K, Summers JL. Nucleolar changes and fibrillarin redistribution following apatone treatment of human bladder carcinoma cells. J Histochem Cytochem. 2010 Jul;58(7):635-51. doi: 10.1369/jhc.2010.956284. Epub 2010 Apr 12. PMID: 20385787; PMCID: PMC2889405.


    Gilloteaux J, Jamison JM, Arnold D, Neal DR, Summers JL. Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jan;288(1):58-83. doi: 10.1002/ar.a.20276. PMID: 16345077.
    [T24 Cell Line] Gilloteaux, Jacques, et al. "Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells." Ultrastructural pathology 25.3 (2001): 183-192.


    Kassouf W, Highshaw R, Nelkin GM, Dinney CP, Kamat AM. Vitamins C and K3 sensitize human urothelial tumors to gemcitabine. J Urol. 2006 Oct;176(4 Pt 1):1642-7. doi: 10.1016/j.juro.2006.06.042. PMID: 16952707.

    Brain Cancer

    Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Aoki I, Obata T, Higashi T, Bakalova R. Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State. Cancers (Basel). 2022 Jan 19;14(3):485. doi: 10.3390/cancers14030485. PMID: 35158753; PMCID: PMC8833725. Link.
    Despotović A, Mirčić A, Misirlić-Denčić S, Harhaji-Trajković L, Trajković V, Zogović N, Tovilović-Kovačević G. Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 23;2022:2998132. doi: 10.1155/2022/2998132. PMID: 35368869; PMCID: PMC8967583. Link.


    Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Zlateva G, Aoki I, Bakalova R. Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug - Comparison With the Chemotherapeutic Standard-of-care Temozolomide. Anticancer Res. 2021 Dec;41(12):6067-6076. doi: 10.21873/anticanres.15426. PMID: 34848461. Link.


    Vita MF, Nagachar N, Avramidis D, Delwar ZM, Cruz MH, Siden Å, Paulsson KM, Yakisich JS. Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C. Invest New Drugs. 2011 Dec;29(6):1314-20. doi: 10.1007/s10637-010-9489-0. Epub 2010 Jul 13. PMID: 20625795; PMCID: PMC3171656. Link.

    Breast Cancer

    Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells: Bajor M, Graczyk-Jarzynka A, Marhelava K, Kurkowiak M, Rahman A, Aura C, Russell N, Zych AO, Firczuk M, Winiarska M, Gallagher WM, Zagozdzon R. Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells. Antioxidants (Basel). 2020 Apr 16;9(4):320. doi: 10.3390/antiox9040320. PMID: 32316111; PMCID: PMC7222372.


    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

    Dejeans N, Tajeddine N, Beck R, Verrax J, Taper H, Gailly P, Calderon PB. Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells. Biochem Pharmacol. 2010 May 1;79(9):1221-30. doi: 10.1016/j.bcp.2009.12.009. Epub 2009 Dec 16. PMID: 20006589.


    Beck R, Verrax J, Dejeans N, Taper H, Calderon PB. Menadione reduction by pharmacological doses of ascorbate induces an oxidative stress that kills breast cancer cells. Int J Toxicol. 2009 Jan-Feb;28(1):33-42. doi: 10.1177/1091581809333139. PMID: 19482829.

    Colon Cancer

    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

    A D'Odorico, G C Sturniolo, R F Bilton, A I Morris, I T Gilmore, R Naccarato, Quinone-induced DNA single strand breaks in a human colon carcinoma cell line., Carcinogenesis, Volume 18, Issue 1, Jan 1997, Pages 43–46, https://doi.org/10.1093/carcin/18.1.43

    Leukemia

    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Beck R, Pedrosa RC, Dejeans N, Glorieux C, Levêque P, Gallez B, Taper H, Eeckhoudt S, Knoops L, Calderon PB, Verrax J. Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study. Invest New Drugs. 2011 Oct;29(5):891-900. doi: 10.1007/s10637-010-9441-3. Epub 2010 May 8. PMID: 20454833.


    Beck R, Verrax J, Gonze T, Zappone M, Pedrosa RC, Taper H, Feron O, Calderon PB. Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death. Biochem Pharmacol. 2009 Feb 1;77(3):375-83. doi: 10.1016/j.bcp.2008.10.019. Epub 2008 Oct 28. PMID: 19014912.

    Verrax J, Delvaux M, Beghein N, Taper H, Gallez B, Buc Calderon P. Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study. Free Radic Res. 2005 Jun;39(6):649-57. doi: 10.1080/10715760500097906. PMID: 16036343.


    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib: Ivanova D, Zhelev Z, Lazarova D, Getsov P, Bakalova R, Aoki I. Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib. Anticancer Res. 2018 Mar;38(3):1407-1414. doi: 10.21873/anticanres.12364. PMID: 29491065.

    CK3 kills cancer cells, leaving healthy cells intact: Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.
    [K562 Cell Line] Verrax J, Vanbever S, Stockis J, Taper H, Calderon PB. Role of glycolysis inhibition and poly (ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells. Int J Cancer. 2007 Mar 15;120(6):1192-7. doi: 10.1002/ijc.22439. PMID: 17163414.

    Liver Cancer

    Verrax J, Cadrobbi J, Marques C, Taper H, Habraken Y, Piette J, Calderon PB. Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death. Apoptosis. 2004 Mar;9(2):223-33. doi: 10.1023/B:APPT.0000018804.26026.1a. PMID: 15004519.

    Melanoma

    Tremante E, Santarelli L, Lo Monaco E, Sampaoli C, Ingegnere T, Guerrieri R, Tomasetti M, Giacomini P. Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis. Oncotarget. 2015 Oct 13;6(31):31039-49. doi: 10.18632/oncotarget.5024. PMID: 26427039; PMCID: PMC4741587.

    Ovarian Cancer

    Jacques Gilloteaux, H. Lee Lau, Ioulia Gourari, Deborah Neal, James M. Jamison, J.L. Summers, Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment, Translational Research in Anatomy, Volume 1, 2015, Pages 25-39, ISSN 2214-854X.

    Prostate Cancer

    Gilloteaux J, Jamison JM, Summers JL. Pro-oxidant treatment of human prostate carcinoma (DU145) induces autoschizis cell death: autophagosomes build up out of injured endomembranes and mitochondria. Ultrastruct Pathol. 2014 Oct;38(5):315-28. doi: 10.3109/01913123.2014.927404. Epub 2014 Jun 23. PMID: 24955925.


    Tareen B, Summers JL, Jamison JM, Neal DR, McGuire K, Gerson L, Diokno A. A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy. Int J Med Sci. 2008 Mar 24;5(2):62-7. doi: 10.7150/ijms.5.62. PMID: 18392145; PMCID: PMC2288789.


    Gilloteaux J, Jamison JM, Neal DR, Summers JL. Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination. Ultrastruct Pathol. 2005 May-Aug;29(3-4):221-35. doi: 10.1080/01913120590951239. PMID: 16036878.


    Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer. Med Oncol. 2003;20(1):45-52. doi: 10.1385/mo:20:1:45. PMID: 12665684.

    General Cancer Studies

    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress: Ren X, Santhosh SM, Coppo L, Ogata FT, Lu J, Holmgren A. The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress. Free Radic Biol Med. 2019 Apr;134:350-358. doi: 10.1016/j.freeradbiomed.2019.01.037. Epub 2019 Jan 28. PMID: 30703479.


    Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation: Kizhuveetil U, Omer S, Karunagaran D, Suraishkumar GK. Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation. Sci Rep. 2020 Jan 31;10(1):1588. doi: 10.1038/s41598-020-58579-2. PMID: 32005913; PMCID: PMC6994657.


    Taper HS. Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3. Anticancer Res. 2008 Sep-Oct;28(5A):2727-32. PMID: 19035302.

    Bladder Cancer

    Gilloteaux J, Jamison JM, Neal DR, Loukas M, Doberzstyn T, Summers JL. Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione. Ultrastruct Pathol. 2010 May;34(3):140-60. doi: 10.3109/01913121003662304. PMID: 20455663.


    Jamison JM, Gilloteaux J, Perlaky L, Thiry M, Smetana K, Neal D, McGuire K, Summers JL. Nucleolar changes and fibrillarin redistribution following apatone treatment of human bladder carcinoma cells. J Histochem Cytochem. 2010 Jul;58(7):635-51. doi: 10.1369/jhc.2010.956284. Epub 2010 Apr 12. PMID: 20385787; PMCID: PMC2889405.


    Gilloteaux J, Jamison JM, Arnold D, Neal DR, Summers JL. Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jan;288(1):58-83. doi: 10.1002/ar.a.20276. PMID: 16345077.
    [T24 Cell Line] Gilloteaux, Jacques, et al. "Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells." Ultrastructural pathology 25.3 (2001): 183-192.


    Kassouf W, Highshaw R, Nelkin GM, Dinney CP, Kamat AM. Vitamins C and K3 sensitize human urothelial tumors to gemcitabine. J Urol. 2006 Oct;176(4 Pt 1):1642-7. doi: 10.1016/j.juro.2006.06.042. PMID: 16952707.

    Brain Cancer

    Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Aoki I, Obata T, Higashi T, Bakalova R. Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State. Cancers (Basel). 2022 Jan 19;14(3):485. doi: 10.3390/cancers14030485. PMID: 35158753; PMCID: PMC8833725. Link.
    Despotović A, Mirčić A, Misirlić-Denčić S, Harhaji-Trajković L, Trajković V, Zogović N, Tovilović-Kovačević G. Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 23;2022:2998132. doi: 10.1155/2022/2998132. PMID: 35368869; PMCID: PMC8967583. Link.


    Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Zlateva G, Aoki I, Bakalova R. Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug - Comparison With the Chemotherapeutic Standard-of-care Temozolomide. Anticancer Res. 2021 Dec;41(12):6067-6076. doi: 10.21873/anticanres.15426. PMID: 34848461. Link.


    Vita MF, Nagachar N, Avramidis D, Delwar ZM, Cruz MH, Siden Å, Paulsson KM, Yakisich JS. Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C. Invest New Drugs. 2011 Dec;29(6):1314-20. doi: 10.1007/s10637-010-9489-0. Epub 2010 Jul 13. PMID: 20625795; PMCID: PMC3171656. Link.

    Breast Cancer

    Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells: Bajor M, Graczyk-Jarzynka A, Marhelava K, Kurkowiak M, Rahman A, Aura C, Russell N, Zych AO, Firczuk M, Winiarska M, Gallagher WM, Zagozdzon R. Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells. Antioxidants (Basel). 2020 Apr 16;9(4):320. doi: 10.3390/antiox9040320. PMID: 32316111; PMCID: PMC7222372.


    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

    Dejeans N, Tajeddine N, Beck R, Verrax J, Taper H, Gailly P, Calderon PB. Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells. Biochem Pharmacol. 2010 May 1;79(9):1221-30. doi: 10.1016/j.bcp.2009.12.009. Epub 2009 Dec 16. PMID: 20006589.


    Beck R, Verrax J, Dejeans N, Taper H, Calderon PB. Menadione reduction by pharmacological doses of ascorbate induces an oxidative stress that kills breast cancer cells. Int J Toxicol. 2009 Jan-Feb;28(1):33-42. doi: 10.1177/1091581809333139. PMID: 19482829.

    Colon Cancer

    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

    A D'Odorico, G C Sturniolo, R F Bilton, A I Morris, I T Gilmore, R Naccarato, Quinone-induced DNA single strand breaks in a human colon carcinoma cell line., Carcinogenesis, Volume 18, Issue 1, Jan 1997, Pages 43–46, https://doi.org/10.1093/carcin/18.1.43

    Leukemia

    Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

    Beck R, Pedrosa RC, Dejeans N, Glorieux C, Levêque P, Gallez B, Taper H, Eeckhoudt S, Knoops L, Calderon PB, Verrax J. Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study. Invest New Drugs. 2011 Oct;29(5):891-900. doi: 10.1007/s10637-010-9441-3. Epub 2010 May 8. PMID: 20454833.


    Beck R, Verrax J, Gonze T, Zappone M, Pedrosa RC, Taper H, Feron O, Calderon PB. Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death. Biochem Pharmacol. 2009 Feb 1;77(3):375-83. doi: 10.1016/j.bcp.2008.10.019. Epub 2008 Oct 28. PMID: 19014912.

    Verrax J, Delvaux M, Beghein N, Taper H, Gallez B, Buc Calderon P. Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study. Free Radic Res. 2005 Jun;39(6):649-57. doi: 10.1080/10715760500097906. PMID: 16036343.


    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib: Ivanova D, Zhelev Z, Lazarova D, Getsov P, Bakalova R, Aoki I. Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib. Anticancer Res. 2018 Mar;38(3):1407-1414. doi: 10.21873/anticanres.12364. PMID: 29491065.

    CK3 kills cancer cells, leaving healthy cells intact: Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.
    [K562 Cell Line] Verrax J, Vanbever S, Stockis J, Taper H, Calderon PB. Role of glycolysis inhibition and poly (ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells. Int J Cancer. 2007 Mar 15;120(6):1192-7. doi: 10.1002/ijc.22439. PMID: 17163414.

    Liver Cancer

    Verrax J, Cadrobbi J, Marques C, Taper H, Habraken Y, Piette J, Calderon PB. Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death. Apoptosis. 2004 Mar;9(2):223-33. doi: 10.1023/B:APPT.0000018804.26026.1a. PMID: 15004519.

    Melanoma

    Tremante E, Santarelli L, Lo Monaco E, Sampaoli C, Ingegnere T, Guerrieri R, Tomasetti M, Giacomini P. Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis. Oncotarget. 2015 Oct 13;6(31):31039-49. doi: 10.18632/oncotarget.5024. PMID: 26427039; PMCID: PMC4741587.

    Ovarian Cancer

    Jacques Gilloteaux, H. Lee Lau, Ioulia Gourari, Deborah Neal, James M. Jamison, J.L. Summers, Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment, Translational Research in Anatomy, Volume 1, 2015, Pages 25-39, ISSN 2214-854X.

    Prostate Cancer

    Gilloteaux J, Jamison JM, Summers JL. Pro-oxidant treatment of human prostate carcinoma (DU145) induces autoschizis cell death: autophagosomes build up out of injured endomembranes and mitochondria. Ultrastruct Pathol. 2014 Oct;38(5):315-28. doi: 10.3109/01913123.2014.927404. Epub 2014 Jun 23. PMID: 24955925.


    Tareen B, Summers JL, Jamison JM, Neal DR, McGuire K, Gerson L, Diokno A. A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy. Int J Med Sci. 2008 Mar 24;5(2):62-7. doi: 10.7150/ijms.5.62. PMID: 18392145; PMCID: PMC2288789.


    Gilloteaux J, Jamison JM, Neal DR, Summers JL. Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination. Ultrastruct Pathol. 2005 May-Aug;29(3-4):221-35. doi: 10.1080/01913120590951239. PMID: 16036878.


    Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer. Med Oncol. 2003;20(1):45-52. doi: 10.1385/mo:20:1:45. PMID: 12665684.

    General Cancer Studies

    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress: Ren X, Santhosh SM, Coppo L, Ogata FT, Lu J, Holmgren A. The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress. Free Radic Biol Med. 2019 Apr;134:350-358. doi: 10.1016/j.freeradbiomed.2019.01.037. Epub 2019 Jan 28. PMID: 30703479.


    Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation: Kizhuveetil U, Omer S, Karunagaran D, Suraishkumar GK. Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation. Sci Rep. 2020 Jan 31;10(1):1588. doi: 10.1038/s41598-020-58579-2. PMID: 32005913; PMCID: PMC6994657.


    Taper HS. Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3. Anticancer Res. 2008 Sep-Oct;28(5A):2727-32. PMID: 19035302.

    C-Max
    C-Max
    C-Max
    C-Max
    C-Max
    C-Max
    C-Max
    C-Max

    C-Max

    $225.00
    Many in stock
    Description

     

    • Synergistic vitamins shown to kill 10-times cancer more efficiently than high-dose vitamin C alone
    • Unlike conventional therapies, C-Max is safe to normal human cells
    • Delivered via liposomes sized for maximum tumor absorption
    • Made in USA at FDA, GMP-certified facilities
    • Drinkable and portable: IV doses anywhere
    • Non-GMO; soy, gluten, sugar, alcohol, allergen, and heavy metal-free.